可溶性FNDC4（人、小鼠、大鼠）重组蛋白，生物素标记

产品名称：可溶性FNDC4（人、小鼠、大鼠）重组蛋白 ，生物素标记

英文名称：Soluble FNDC4 (Human, Mouse, Rat) Recombinant Biotinylated

产品编号：00386-02-50B

规格：50 ug

• Soluble Fibronectin type III Domain-Containing Protein 4 (FNDC4) is a secreted anti-inflammatory factor, upregulated in inflammatory bowel disease.

• The novel adipokine FNDC4 reduces lipogenesis and increases fat browning in human visceral adipocytes. (Frühbeck G, et al. FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes. Metabolism. 2020 Jul;108:154261)

• FNDC4 acts as an anti-inflammatory factor

New References of FNDC4 Research:

• Georgiadi A, et al. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nat Commun. 2021 May 20;12(1):2999

• Daudon M, Bigot Y, Dupont J, Price CA. Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction. Reproduction. 2022 May 23;164(1):R1-R9

• Frühbeck G, et al., Rodríguez A. FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes. Cell Mol Immunol. 2021 Oct;18(10):2457-2459.

• FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB and CXCL10 Expression. Lv ZT et al. Biomed Res Int. 2018 May 30;2018:3936257.

Features

• Code No.: 00386-02-50B

  Size: 50 ug

  Protein ID: NP_073734.1

  Gene ID:NM_022823.2
  Sequence: Asp45-Thr167

  MW:15 KD (non-glycosylated)

  Tag: His Tag on N-Terminus

  Expressed: Human cells

  Purity: 95%

  Data Sheet: PDF