Ependymin Related Protein 1(EPDR1)（人）重组蛋白
产品名称：Ependymin Related Protein 1(EPDR1)（人）重组蛋白
英文名称：Human Ependymin Related Protein 1(EPDR1) Recombinant
产品编号：00023-01-10
规格：10 ug
厂家：Aviscera Bioscience
New Batokine EPDR1 ELISA 2025 Products
EPDR1 (Ependymin-Related Protein 1): A Circulating Biomarker for Obesity, Metabolism Syndrome.
How EPDR1 affects adipocytes
• EPDR1 is released from brown and white adipocytes.
• EPDR1 is important for the development of brown adipocytes into functional thermogenic adipocytes.
• EPDR1 deficiency in mice leads to a 50% increase in body fat.
• EPDR1 deficiency in mice also lowers oxygen consumption and physical activity .
How EPDR1 affects other tissues
• EPDR1 regulates the expression of mitochondrial proteins in pancreatic islets and β-cells.
• EPDR1 regulates osteoblast metabolism and maturation.
• EPDR1 may influence the cross-talk between bone and glucose homeostasis.
• EPDR1 is a potential drug target for improving metabolic control.
EPDR1 as an adipokine secreted from adipocytes enables to regulate energy balance and thermogenesis. It’s also involved in regulating the metabolism of pancreatic islets and osteoblasts. EPDR1 is highly expressed in the brain and is also detected in other tissues, such as Adipose Tissue, muscle,heart, Kidney and pancreas.
Deshmukh, Atul S. et al.Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine. Cell Metabolism, Volume 30, Issue 5, 963 - 975.e7
Ependymin-Related Protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat.
Model of EPDR1 regulation of β-cell metabolism and function. EPDR1 can regulate β-cell metabolism by binding and signaling through a not yet identified plasma membrane receptor or be taken up to act intracellularly. EPDR1 positively regulates GSIS of β-cells by increasing the coupling of glucose metabolism to mitochondrial TCA cycle.
Cataldo LR, et al. The human batokine EPDR1 regulates β-cell metabolism and function. Mol Metab. 2022 Dec;66:101629.
| Product Name | Catalog No. | Size |
| Human EPDR1 ELISA Kit (Serum, Plasma) | SK00023-06 | 192 T |
| High Sensitivity Human EPDR1 ELISA Kit (Serum, Plasma) | SK00023-16 | 192 T |
| Human EPDR1 His Tag (HEK293) | A00023-01-10 | 10 mg |
| Anti Human EPDR1 IgG Biotinylated (WB) | A00023-01-20B | 20 mL |
| Anti EPDR1 Antibody Pre-coated Microplate | 023-02-01 | 96 T |
| Human EPDR1 Protein Pre-coated Microplate | PL00023-01-01 | 96 T |
Ahmed T, et al. EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex. J Biol Chem. 2022 Sep;298(9):102297.
