Endotrophin (ETP) A New Peptide Fragment from the C-Terminal Globular Domain of Collagen 6A3 is A Novel Biomarker for Fibrosis, Cardiovascular Disease (HF, CAD), Obesity, Insulin Resistance and Cancer Research.
 

How endotrophin affects metabolism and Obesity:

 

• Fibrosis: Endotrophin can trigger fibrosis in adipose tissue, which can lead to metabolic dysfunction.

 

• Inflammation: Endotrophin can trigger inflammation in adipose tissue, which can lead to metabolic dysfunction.

 

• Insulin resistance: Endotrophin can contribute to insulin resistance, which can lead to metabolic dysfunction.

 

• Autophagic flux impairment: High levels of endotrophin can impair autophagic flux in adipocytes, which can contribute to metabolic dysfunction.

 

• Endotrophin as a treatment target: Endotrophin has been identified as a potential target for treating obesity and other metabolic dysfunctions. It has also been shown to drive pathological changes, and thereby can serve as a drug target.

 

• Endotrophin in disease: Endotrophin levels have been associated with disease severity in multiple disease states, including heart failure, polycystic ovary syndrome, and diabet.

 

Endotrophin is a peptide from Collagen 6A3 that’s linked to obesity and metabolic dysfunction. High levels of endotrophin in adipocytes are associated with insulin resistance, inflammation, and apoptosis.
 

 

 

 

The COL6A3 gene is expressed in a variety of tissues, including the brain, adipose tissue, pancreas and heart.

 

• Brain: In the adult mouse brain, COL6A3 is expressed throughout, with the highest

 

levels in the midbrain and brainstem. Neurons, but not astroglia, are the cellular

 

source of COL6A3 in the brain.

 

• Adipose tissue: COL6A3 expression in adipocytes is associated with insulin resistance

 

COL6A3 expression in adipocytes depends on adipocyte size and PPARγ

 

• Pancreas: In the normal pancreas, COL6A3 is expressed in the connective tissue

 

around the ducts.

 

• Heart: The COL6A3 gene is expressed primarily within cardiac fibroblasts. Elevated

 

expression of COL6A3 is linked to cardiac fibrosis or coronary artery disease, a

 

condition where excessive extracellular matrix is produced in response to injury

 

or stress.

 

Studies have investigated the potential of targeting COL6A3-derived peptides like “endotrophin” as a therapeutic approach for heart disease due to its role in fibrosis development.

 

 

 

Feature of Aviscera Bioscience’s Human Endotrophin ELISA Kit:

 

• Antibody Pair High Sensitivity formulation.

 

• Validated on Western Blot.

 

• Calibation by human Endotrophin His Tag derived from

 

HEK293 which with three disulfide bonds.

 

• Endogenous Endotrophin Peptide Tested.

 

 

 

 

 

 

Human Endotrophin (Ala1-Thr91)

 

1 ARSASSSTINLMVSTEPLALTETDICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENK

 

FGSQKECEKVCAPVLAKPGVISVMGT 91

 

 

 

 

MOUSE ENDOTROPHIN (A1-V82)

 

1AHRASSST INLMVNTEPL FLTKTDICKL SRDAGTCVDF KLLWHYDLES KSCKRFWYGG CGGNENRFHS QEECEKMCSP ELTV 82

 

 

 

 

 

            

 

 

 

 

 

 

 

 

 

Product Name	Catalog No.	Size
Human Endotrophin (ETP) ELISA Kit (Serum, Plasma, Cell Cultures)	SK00009-08	96 T
Human Endotrophin (ETP) ELISA Kit	SK00009-06	96 T
Mouse Endotrophin ELISA Kit (Serum, Plasma) (3 Plates)	SK00009-03	3 x 96 T
Human Endotrophin His Tag Rec. (A 1-T 91)	00009-01-100	100 mg
Human Endotrophin His Tag (HEK293) ( Thr 1-Thr 77)	0000-06-10	10 mg
Mouse Endotrophin His Tag Rec. (Ala 1- Val 82)	00009-03-100	100 mg
Anti human Endotrophin IgG Biotinylated	A00009-06-50B	50 mL

 

 

 

 

 

Aviscera Bioscience focuses on development of reliable monoclonal anttbodies recombinant proteins and immunoassay kits for neuroscience, cardiovascular diseases, Inffammatton Cancer and metabolism research.

 

Features of New Products: Endotrophin, Irisin/FNDC5, Asprosin, BDNF, Sorttlin, ECP, Myonecttn, ACE2, Neprilysin, LOX-1, Plasma Gelsolin, CD320, CD209, CD73, FAM19A1, FAM19A5, FNDC4, Pro-BMP7B, Isthmin-1, and more

 

Website: www.AvisceraBioscience.net

Email: Info@AvisceraBioscience.com